Which feature in Microsoft Defender for Office 365 helps protect against impersonation attempts in phishing attacks?

The feature that helps protect against impersonation attempts in phishing attacks is configuring anti-phishing policies with targeted impersonation protection. This specific capability is designed to mitigate the risks posed by attackers who might attempt to impersonate trusted individuals or domains in order to deceive users into divulging sensitive information or performing unauthorized actions.

Targeted impersonation protection includes mechanisms that analyze the relationship and communication patterns between users and the purported impersonating source. By scrutinizing factors such as sender reputation and behavioral anomalies, it can identify and block suspicious emails that aim to spoof legitimate entities. This proactive measure is vital in a security strategy, particularly as phishing tactics become increasingly sophisticated.

The other features listed, while important for overall email security, do not specifically address impersonation attacks in the same targeted manner. For instance, enabling safe attachments helps to detect and block harmful files in emails, but it does not directly target the impersonation aspect. Domain spoofing protections focus on preventing spoofed domains from reaching users, whereas Safe Links and Safe Attachments are designed to provide secure access to content and shield against malware. However, they do not specifically analyze the intent behind the sender's identity as targeted impersonation protection does.